alpha-Amanitin, 1MG

SKU:
CAY-17898-1MG
  • $227.00

    • Description

    α-Amanitin, 1MG

    Technical Information
    CAS Number
    23109-05-9
    Molecular Formula
    C39H54N10O14S
    Formula Weight
    919.0
    Purity
    ≥90%
    A crystalline solid
    Solubility
    • Water: 1mg/ml
    λmax
    303 nm
    SMILES
    O=C(N[C@@]1([H])[C@@H](C)[C@@H](O)CO)[C@@]2([H])N(C[C@H](O)C2)C([C@H](CC(N)=O)NC([C@@]([H])(NC(CNC([C@@]([C@H](CC)C)([H])NC(CN3)=O)=O)=O)CS(C4=C(C(C=CC(O)=C5)=C5N4)C[C@@H](C3=O)NC1=O)=O)=O)=O
    InChi Code
    InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46
    InChi Key
    CIORWBWIBBPXCG-JAXJKTSHSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    α-Amanitin is a cyclic peptide found in several species of the Amanita genus as well as other poisonous fungi.1 At 1, 10, and 50 µg/ml, respectively, α-amanitin inhibits RNA polymerase II, III, and IV, preventing translocation of the enzymes on DNA, which significantly slows the rate of transcription.2,3 RNA polymerase I is insensitive to its effects. This toxin is used in molecular biology to distinguish among types of RNA polymerase in a sample and to arrest RNA synthesis in transcription studies.2

    WARNING This product is not for human or veterinary use.