Lithium Chloride, ACS reagent, 500G

SKU:
310468-500G
  • $232.00

    • Description

    Lithium chloride, ACS reagent, ≥99%, 500G

    Linear Formula:
    LiCl
    CAS Number:
    7447-41-8
    Molecular Weight:
    42.39
    EC Number:
    231-212-3
    MDL number:
    MFCD00011078
    PubChem Substance ID:
    329753626
    NACRES:
    NA.21

    PROPERTIES

    grade

    ACS reagent

    Quality Level

    200

    Assay

    ≥99%

    form

    crystalline powder
    powder, crystals or granules

    impurities

    ≤0.008 meq/g Titr. base
    ≤0.01% insolubles

    loss

    ≤1.0% loss on drying

    pH

    6

    mp

    605 °C (lit.)

    anion traces

    sulfate (SO42-): ≤0.01%

    cation traces

    Ba: ≤0.003%
    Ca: ≤0.01%
    Fe: ≤0.001%
    K: ≤0.01%
    Na: ≤0.20%
    heavy metals: ≤0.002% (by ICP)

    SMILES string

    [Li+].[Cl-]

    InChI

    1S/ClH.Li/h1H;/q;+1/p-1

    InChI key

    KWGKDLIKAYFUFQ-UHFFFAOYSA-M

    General description

    Lithium chloride (LiCl) is a lithium salt. It is used as a source of chloride nucleophile as well as a source of chloride ligand in chemical synthesis. LiCl is also used as a desiccant in drying air streams.

    Application

    Lithium chloride can be used as:
    • A source of chloride anion for the conversion of alcohols to alkyl chloride under Mitsunobu conditions.
    • An additive in the palladium-catalyzed coupling and carbonylative coupling reactions of organostannanes and vinyl triflates.
    • A reagent for the cleavage of protecting groups under mild conditions. It readily converts acetals and ketals to the corresponding carbonyl compounds.
    • A reagent in the dehydrohalogenation of α-halocarbonyl compounds to α,β-unsaturated carbonyls compound in the presence of DMF.

    LiCl is also used with other reagents:
    • LiCl:DIPEA (1:1 molar ratio) is used in Horner–Wadsworth–Emmons alkenation reaction.
    • LiCl:Hexamethylphosphoric triamide is used in decarboxylative alkylation and chloride displacement reactions.
    • LiCl is used as an additive in solid-phase peptide synthesis because it increases resin swelling and improves the efficiencies of complex coupling steps.

    Features and Benefits

    • Easy to handle
    • Weak Lewis acid
    • Highly soluble in water