Lamotrigine, 50MG

SKU:
CAY-15428-50MG
  • $152.00

    • Description

    Lamotrigine, 50MG

    Item No. 15428

    Technical Information
    Formal Name
    6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
    CAS Number
    84057-84-1
    Synonyms
    • BW 430C
    • LTG
    Molecular Formula
    C9H7Cl2N5
    Formula Weight
    256.1
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility(Learn about Variance in Solubility)
    • DMF: 10 mg/ml
    • DMSO: 10 mg/ml
    • DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
    • Ethanol: 2 mg/ml
    SMILES
    ClC1=C(Cl)C(C2=NN=C(N)N=C2N)=CC=C1
    InChi Code
    InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
    InChi Key
    PYZRQGJRPPTADH-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Lamotrigine is an anticonvulsant.1 It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA (Item No. 24114) and P-type calcium channel blocker ω-agatoxin IVA (Item No. 21605).1,2 Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).3 It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).1 Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.

    WARNING This product is not for human or veterinary use.