Imipramine (hydrochloride), 1G

SKU:
CAY-15890-1G
  • $32.00

    • Description

    Imipramine (hydrochloride)

    Item No. 15890

    Technical Information
    Formal Name
    10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, monohydrochloride
    CAS Number
    113-52-0
    Synonyms
    • Melipramine
    Molecular Formula
    C19H24N2 • HCl
    Formula Weight
    316.9
    Purity
    ≥98%
    Formulation
    A crystalline solid
    Solubility
    • DMF: 25 mg/ml
    • DMSO: 25 mg/ml
    • Ethanol: 25 mg/ml
    • PBS (pH 7.2): 0.5 mg/ml
    λmax
    212, 250 nm
    SMILES
    CN(C)CCCN1C2=C(C=CC=C2)CCC3=C1C=CC=C3.Cl
    InChi Code
    InChI=1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
    InChi Key
    XZZXIYZZBJDEEP-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Imipramine is a first generation tricyclic antidepressant.1 It inhibits serotonin (5-HT) uptake by isolated human platelets by 54 and 79% when used at concentrations of 1 and 4 µg/ml, respectively, and inhibits norepinephrine uptake in rat brain by 63% when administered at a dose of 20 mg/kg.2,3 It also binds to histamine H1, M1 muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 37, 46, and 32 nM, respectively).4 Imipramine (10 and 20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681).5 Formulations containing imipramine have been used in the treatment of depression and as an adjunct in the treatment of childhood enuresis.

    WARNING This product is not for human or veterinary use.