Doxepin (hydrochloride) 1G

SKU:
CAY-15888-1G
  • $37.00

    • Description

    Doxepin (hydrochloride)

    Item No. 15888

    Technical Information
    Formal Name
    3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-1-propanamine, monohydrochloride
    CAS Number
    1229-29-4
    Molecular Formula
    C19H21NO • HCl
    Formula Weight
    315.8
    Purity
    ≥95%
    Formulation
    A crystalline solid
    Solubility
    • DMF: 20 mg/ml
    • DMSO: 25 mg/ml
    • Ethanol: 30 mg/ml
    • PBS (pH 7.2): 10 mg/ml
    λmax
    296 nm
    SMILES
    CN(C)CC/C=C1C2=C(C=CC=C2)COC3=C/1C=CC=C3.Cl
    InChi Code
    InChI=1S/C19H21NO.ClH/c1-20(2)13-7-11-17-16-9-4-3-8-15(16)14-21-19-12-6-5-10-18(17)19;/h3-6,8-12H,7,13-14H2,1-2H3;1H/b17-11-;
    InChi Key
    MHNSPTUQQIYJOT-CULRIWENSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Doxepin is a tricyclic antidepressant that binds to the serotonin (5-HT) transporter (SERT) and norepinephrine transporter (NET; Kds = 68 and 29.5 nM, respectively).1 It is a histamine H1 receptor antagonist (Ki = 1.23 nM).2 Doxepin selectively binds to SERT and NET over the dopamine transporter (DAT; Kd = 12,100 nM) and inhibits histamine H1 over H2, H3, and H4 receptors (Kis = 170, 39,810, and 15,135 nM, respectively).1,2 It also binds to the 5-HT2 receptor, as well as to muscarinic acetylcholine and α1-adrenergic receptors (α1-ARs; Kds = 27, 23, and 23.5 nM, respectively).3 Doxepin (10 mg/kg, i.p.) decreases allodynia and hyperalgesia in a mouse model of chronic constriction injury-induced neuropathic pain.4 It increases the distance traveled in the center of the open field test and reduces immobility time in the forced swim test in a mouse model of depression induced by chronic stress when administered orally at a dose of 15 mg/kg.5 Formulations containing doxepin have been used in the treatment of depression and insomnia.

    WARNING This product is not for human or veterinary use.