Betulinic Acid, 50MG

SKU:
CAY-11686-50MG
  • $36.00

    • Description

    Betulinic Acid, 50MG

    Technical Information
    Formal Name
    3β-hydroxy-lup-20(29)-en-28-oic acid
    CAS Number
    472-15-1
    Synonyms
    • Lupatic Acid
    • NSC 113090
    Molecular Formula
    C30H48O3
    Formula Weight
    456.7
    Purity
    ≥97%
    Formulation(Request formulation change)
    A solid
    Solubility
    • DMF: 15 mg/ml
    • DMSO: 20 mg/ml
    • DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
    • Ethanol: 0.5 mg/ml
    SMILES
    CC([C@@H]1CC[C@]2(C(O)=O)CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]3([H])[C@]21[H])=C
    InChi Code
    InChI=1S/C30H48O3/c1-18(2)19-10-15-30(25(32)33)17-16-28(6)20(24(19)30)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h19-24,31H,1,8-17H2,2-7H3,(H,32,33)/t19-,20+,21-,22+,23-,24+,27-,28+,29+,30-/m0/s1
    InChi Key
    QGJZLNKBHJESQX-FZFNOLFKSA-N
    Origin
    Plant/Crataeva nurvala Betula alba
    Shipping & Storage Information
    Storage
    4°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Betulinic acid is a natural plant triterpenoid that is structurally related to mammalian bile acids. It is an agonist of the G protein-coupled bile acid receptor TGR5 (EC50 = 1 µM), which might be linked with its ability to alter gene expression and fatty liver development in cells and mice given ethanol.1,2,3 Betulinic acid also reduces NF-κB signaling and expression of microRNA-33 in LPS-treated macrophages, increasing levels of the ATP-binding cassette (ABC) cholesterol transporter ABCA1.4 It also inhibits replication of HIV-1 (IC50 = 1.4 µM) and has cytotoxic effects against cancer cells.3,5

    WARNING This product is not for human or veterinary use.