Yangonin, 1MG

SKU:
CAY-14351-1MG
  • $62.00

    • Description

    Yangonin

    Yangonin is a natural kavalactone from the kava plant, P. methysticum. It enhances the binding of bicuculline at the γ-amino butyric acid (GABA) receptor GABAA at 1.0 µM.1 Yangonin also binds the central cannabinoid (CB1) receptor with a Ki value of 0.72 µM, but whether it serves as an agonist or antagonist at this receptor remains to be determined.2 Yangonin blocks the activation of NF-κB by TNF-α.3 It also inhibits anchorage-dependent and independent growth of bladder cancer cell lines through induction of autophagic cell death (IC50s = 15-59 mg/mL).4

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    4-methoxy-6-[(1E)-2-(4-methoxyphenyl)ethenyl]-2H-pyran-2-one
    CAS Number
    500-62-9
    Molecular Formula
    C15H14O4
    Formula Weight
    258.3
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 5 mg/ml
    • DMSO: 5 mg/ml
    • DMSO:PBS(pH 7.2) (1:2): 0.3 mg/ml
    λmax
    218, 267, 357 nm
    SMILES
    COC1=CC=C(/C=C/C(O2)=CC(OC)=CC2=O)C=C1
    InChi Code
    InChI=1S/C15H14O4/c1-17-12-6-3-11(4-7-12)5-8-13-9-14(18-2)10-15(16)19-13/h3-10H,1-2H3/b8-5+
    InChi Key
    XLHIYUYCSMZCCC-VMPITWQZSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 2 years
    Technical Support & Resources

    Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ.