Trifluorothymidine, by HPLC, 100MG

SKU:
T2255-100MG
  • $288.00

    • Description

    Trifluorothymidine, ≥99% by HPLC, 100MG

    Synonym(s):
    α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine
    Empirical Formula (Hill Notation):
    C10H11F3N2O5
    CAS Number:
    70-00-8
    Molecular Weight:
    296.20
    EC Number:
    200-722-8
    MDL number:
    MFCD00006534
    PubChem Substance ID:
    24900027
    NACRES:
    NA.51

    PROPERTIES

    biological source

    synthetic

    Quality Level

    100

    assay

    ≥99% (HPLC)

    form

    powder

    mp

    190-193 °C (lit.)

    solubility

    water: 50 mg/mL, clear, colorless

    storage temp.

    −20°C

    SMILES string

    OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F

    InChI

    1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1

    InChI key

    VSQQQLOSPVPRAZ-RRKCRQDMSA-N

    DESCRIPTION

    Application

    Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells,[1] human lymphoblastoid TK6 cells,[2] and L5178Y mouse lymphoma cells.[3]

    Biochem/physiol Actions

    Trifluorothymidine is a thymidine analog[4] and is light sensitive.[1] TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics.[5] Incorporation of phosphorylated TFT into DNA induces damage,[6] making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase[5] and in screening mutant thymidine kinase gene.[1]. It elicits antitumor activity in gastrointestinal (GI) cancers[7] and has therapeutic potential to treat herpetic keratitis.[4]

    Packaging

    Bottomless glass bottle. Contents are inside inserted fused cone.

    SAFETY INFORMATION

    Signal Word

    Warning

    Hazard Statements

    H341 - H351 - H361d

    Precautionary Statements

    P201 - P202 - P280 - P308 + P313 - P405 - P501

    Hazard Classifications

    Carc. 2 - Muta. 2 - Repr. 2

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves