Trifluoroacetic Acid, 1L

SKU:
T6508-1L
  • $724.00

    • Description

    Trifluoroacetic Acid, 1L

    ReagentPlus®, 99%

    Synonym(s):
    TFA
    Linear Formula:
    CF3COOH
    CAS Number:
    76-05-1
    Molecular Weight:
    114.02
    Beilstein:
    742035
    EC Number:
    200-929-3
    MDL number:
    MFCD00004169
    PubChem Substance ID:
    329826846
    NACRES:
    NA.21

    PROPERTIES

    vapor density

    3.9 (vs air)

    Quality Level

    200

    vapor pressure

    97.5 mmHg ( 20 °C)

    product line

    ReagentPlus®

    Assay

    99%

    form

    liquid

    impurities

    ≤0.05% water

    refractive index

    n20/D 1.3 (lit.)

    pH

    1 (10 g/L)

    bp

    72.4 °C (lit.)

    mp

    −15.4 °C (lit.)

    solubility

    ethanol: soluble 0.33 mL/mL

    density

    1.489 g/mL at 20 °C (lit.)

    SMILES string

    OC(C(F)(F)F)=O

    InChI

    1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

    InChI key

    DTQVDTLACAAQTR-UHFFFAOYSA-N

    General description

    Trifluoroacetic acid (TFA) is an organofluorine compound used as a reagent in organic synthesis for various acid-catalyzed reactions such as ring-opening of epoxides, biomimetic cyclization, Cope rearrangements, and natural product synthesis. TFA′s physicochemical characteristics provide advantages over other acids because of its high volatility, solubility in organic solvents, and acidic strength. When TFA is used as a reagent the product isolation is simple by evaporation due to its very high volatility. Less volatile acids such as sulfuric acid or p-toluenesulfonic acid may require neutralization or an extractive workup.[1]

    Application

    Trifluoroacetic acid can be used as a reagent:
    • For the cleavage of nitrogen and oxygen protecting groups such as N-Boc, N-benzyloxymethyl, benzyl ether, p-methoxybenzyl ether, t-butyl ether, t-butyloxymethyl ether, triphenylmethyl ether, and dimethyl acetals.[1][2][3]
    • In the Baeyer–Villiger oxidation reactions in combination with sodium percarbonate.[1],·
    • For the C-H trifluoromethylation of arenes.[4]

    TFA can also be used as:
    • A solvent in atom transfer cyclization reactions and polymer processes.[2]
    • A catalyst in the synthesis of ε-caprolactam via Beckmann rearrangement of cyclohexanone oxime in aprotic solvents.[5]

    Packaging

    1mL in each ampule.

    Legal Information

    ReagentPlus is a registered trademark of Sigma-Aldrich Co. LLC