Spiromesifen-d₉ is intended for use as an internal standard for the quantification of spiromesifen (Item No. 25822) by GC- or LC-MS. Spiromesifen is an insecticide and acaricide that reduces lipid biosynthesis via inhibition of acetyl-CoA carboxylase.^1,2 It inhibits chitinase from Egyptian cotton leafworm (S. littoralis) larvae (IC₅₀s = 0.60 and 0.72 μM for enzyme isolated from lab and field strains, respectively).³ It induces toxicity in whitefly (T. vaporariorum) nymphs (LC₅₀ = 0.61 mg/L), spider mite (T. cinnabarinus) eggs (LC₅₀ = 0.16 mg/kg), and second instar larvae of S. littoralis lab and field strains (LC₅₀s = 0.44 and 0.68 ppm, respectively, at 72 hours post-application).^1,2,3 Spiromesifen (600 mg/kg) also induces 50, 60, and 70% mortality in the Lepidoptera pests H. armigera, O. nubialis, and P. xylostella, respectively, and induces 100% mortality in M. separata when used at a dose of 100 mg/kg.² It induces toxicity in D. magna (EC₅₀ = >0.092 mg a.s./L) and the fish species O. mykiss and L. macrochirus (LC₅₀s = 0.016 and >0.034 mg a.s./L, respectively) but not rats (LD₅₀ = >2,000 mg/kg).⁴ Spiromesifen also inhibits the human GST isozyme GSTA1-1 (IC₅₀ = 12.1 μM).⁵ Formulations containing spiromesifen have been used as insecticides and miticides in agriculture, as well as commercial, industrial, and residential areas.

WARNING This product is not for human or veterinary use.

This product is sold exclusively for research and analytical uses. It is formulated and packaged for use in controlled laboratory settings. Bulk sizes are not available for purchase.

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