Rimonabant hydrochloride, (HPLC)

SKU:
SML0800-5MG
  • $89.40

    • Description

    Rimonabant hydrochloride ≥98% (HPLC)

    Synonym(s):
    SR-141716A, SR141716, 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-1-piperidinyl-1H-pyrazole-3-carboxamide hydrochloride, SR-141716, SR141716A
    Empirical Formula (Hill Notation):
    C22H21Cl3N4O · HCl
    CAS Number:
    158681-13-1
    Molecular Weight:
    500.25
    PubChem Substance ID:
    329825601
    NACRES:
    NA.77

    Quality Level

    100

    assay

    ≥98% (HPLC)

    form

    powder

    color

    white to beige

    solubility

    DMSO: 20 mg/mL, clear

    storage temp.

    2-8°C

    SMILES string

    CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NN4CCCCC4)=O.Cl

    InChI

    1S/C22H21Cl3N4O.ClH/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-9-17(24)13-18(19)25)21(14)15-5-7-16(23)8-6-15;/h5-10,13H,2-4,11-12H2,1H3,(H,27,30);1H

    InChI key

    REOYOKXLUFHOBV-UHFFFAOYSA-N

    Gene Information

    human ... CNR1(1268)

    Application

    Rimonabant hydrochloride has been used as an antagonist of cannabinoid 1 (CB1) receptor:
    • to study its effects on protein synthesis in C2C12 myotubes
    • to analyze its effects on human astroglia
    • in combination with methanandamide (mAEA) to study its effects on murine gastric vagal afferent mechanosensitivity

    Packaging

    5, 25 mg in glass bottle

    Biochem/physiol Actions

    Rimonabant acts as a mycobacterial membrane protein large 3 (MMPL3) inhibitor. Rimonabant hydrochloride exhibits therapeutic activity against weight reduction and smoking cessation.
    Rimonabant hydrochloride (SR-141716A) is a potent and selective CB1 cannabinoid inverse agonist/antagonist with a Ki of 1.6 nM, minimal affinity for CB2, and and some GPR55 agonist activity. Rimonabant was developed as an anti-obesity drug because of its appetite suppressant activity, but was taken off the market because of side effects of depression and anxiety.

    Features and Benefits

    This compound is featured on the Cannabinoid Receptors and Cannabinoid Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

    Pictograms

    GHS06

    Signal Word

    Danger

    Hazard Statements

    H301 - H319

    Precautionary Statements

    P301 + P310 + P330 - P305 + P351 + P338

    RIDADR

    UN 2811 6.1 / PGIII

    WGK Germany

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable