LY2828360, 1mg, Item No. 26791

SKU:
CAY-26791-1mg
  • $32.00

    • Description

    LY2828360, 1mg, Item No. 26791

    Product Description

    LY2828360 is a cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). It selectively activates CB2 over CB1 in a GTPγS binding assay (EC50s = 20.1 and >100,000 nM, respectively). It reduces differences in hind paw weight bearing between monoiodoacetic acid- and saline-injected knees in a rat model of knee joint-related chronic pain induced by monoiodoacetic acid (MIA) when administered at doses greater than or equal to 0.1 mg/kg. LY2828360 dose-dependently reduces mechanical and cold allodynia induced by paclitaxel (Item No. 10461) in mice and prevents development of morphine tolerance when administered at dose of 3 mg/kg per day for 12 days. It also reduces paclitaxel-induced allodynia in morphine-tolerant mice.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    8-(2-chlorophenyl)-2-methyl-6-(4-methyl-1-piperazinyl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine
    CAS Number
    1231220-79-3
    Molecular Formula
    C22H27ClN6O
    Formula Weight
    426.9
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • Chloroform: 30 mg/ml
    λmax
    219, 284 nm
    SMILES
    CN1CCN(C2=C(N=C(C3=C(Cl)C=CC=C3)N4C5CCOCC5)C4=NC(C)=N2)CC1
    InChi Code
    InChI=1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3
    InChi Key
    UCMNDPDJRSEZPL-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 2 years
    Certificates of Analysis & Batch Specific Data

    Get Batch-Specific Data and Documents by Batch Number

    Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.