Kainic Acid (hydrate), 5MG

SKU:
CAY-78050-5MG
$72.00

Description

(−)-(α)-Kainic Acid (hydrate), 5MG

Product Description

(−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities.1 It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively).2 (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes.3 It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 µM.4 Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal.5 It has been commonly used to induce seizures in rodents.6,7

WARNING This product is not for human or veterinary use.

echnical Information
Formal Name
2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid, monohydrate
CAS Number
58002-62-3
Molecular Formula
C10H15NO4 • H2O
Formula Weight
231.2
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility
  • PBS (pH 7.2): 50 mg/ml
SMILES
[H]N1C[C@H](C(C)=C)[C@H](CC(O)=O)[C@H]1C(O)=O.O
InChi Code
InChI=1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9?;/m0./s1
InChi Key
FZNZRJRSYLQHLT-AQLFBIHGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years