Ganoderic Acid D

SKU:
CAY-26765-1MG
$37.00

Description

Ganoderic Acid D

Ganoderic acid D is an oxygenated triterpenoid that has been found in G. lucidum.1 It inhibits glucose uptake and lactate production when used at concentrations ranging from 50 to 200 µM and decreases pyruvate and acetyl-coenzyme A production at concentrations of 100 and 200 µM in HT-29 and SW620 colon cancer cells. Ganoderic acid D increases protein levels of sirtuin 3 (SIRT3) in HT-29 and SW620 cells. It is cytotoxic to HepG2, HeLa, and Caco-2 cells with IC50 values of 0.14, 0.18, and 0.02 µg/ml, respectively.2

WARNING This product is not for human or veterinary use.

Technical Information
Formal Name
7β-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid
CAS Number
108340-60-9
Molecular Formula
C30H42O7
Formula Weight
514.7
Purity
≥97%
Formulation(Request formulation change)
A crystalline solid
Solubility
  • DMF: 30 mg/ml
  • DMSO: 30 mg/ml
  • Ethanol: 30 mg/ml
  • Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
λmax
254 nm
SMILES
O=C1CC[C@@]2(C)[C@](C[C@H](O)C([C@@](C(C[C@]3([H])[C@H](C)CC(CC(C)C(O)=O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C
InChi Code
InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21+,28+,29-,30+/m1/s1
InChi Key
YTVGSCZIHGRVAV-IYAQLQCNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years