Cypermethrin-d_{5, 1MG}

Cypermethrin-d₅ is intended for use as an internal standard for the quantification of cypermethrin (Item No. 24117) by GC- or LC-MS. Cypermethrin is a type II pyrethroid insecticide.^1,2,3,4 It prolongs opening of sodium channels resulting in membrane depolarization and a conductance block of the insect nervous system, and point mutations in sodium channels induce cypermethrin-resistance in house flies, cockroaches, and mosquitos.³ Cypermethrin (1-1.5 mg) reduces survival of ticks (H. anatolicum) in vitro in a concentration-dependent manner.² Topical administration of cypermethrin reduces the number of ticks on infested cattle. Cypermethrin (5 and 10 ppm) reduces survival of lice (D. ovis) in sheep fleece and prevents re-infestation in contact-challenged sheep for 7 and 19 weeks, respectively.¹ It induces developmental neurotoxicities in zebrafish, increasing mortality and edema and inducing body-axis curvature when used at concentrations ranging from 50 to 200 μg/L.⁵ Cypermethrin (15 mg/kg twice weekly for 24 weeks) also induces Parkinson's disease-like neurodegeneration in rats, decreasing locomotor activity, dopamine production, and the number of tyrosine hydroxylase positive (TH⁺) neurons in the substantia nigra.⁴ Formulations containing cypermethrin have been used in the control of insects in agriculture and on commercial and residential premises.

WARNING This product is not for human or veterinary use.

This product is sold exclusively for research and analytical uses. It is formulated and packaged for use in controlled laboratory settings. Bulk sizes are not available for purchase.