β-Eudesmol is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.^1,2 It is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 µM and increases the decay phase of depolarization when used at a concentration of 100 µM in isolated mouse diaphragm muscle.³ β-Eudesmol (50-100 µM) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs).⁴ It also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 µM and reduces tumor growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats.^5,6

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