Astaxanthin, (HPLC), from Blakeslea trispora, 50mg

SKU:
SML0982-50MG
  • $132.00

    • Description

    Astaxanthin ≥97% (HPLC), from Blakeslea trispora, 50mg

    Synonym: (3S,3′S)-3,3′-Dihydroxy-β,β-Carotene-4,4′-dione, 3,3′-Dihydroxy-β-carotene-4,4′-dione, trans-Astaxanthin

    • CAS Number 472-61-7

       

    • Empirical Formula (Hill Notation) C40H52O4

       

    • Molecular Weight 596.84

    Properties

    Related Categories AN-AZ, Antioxidants and Cytoprotectants, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
    Cell Signaling and Neuroscience, Cell Stress, Nitric Oxide and Cell Stress
    Quality Level 100
    biological source Blakeslea trispora
    assay ≥97% (HPLC)
    form powder
    storage condition desiccated
     - protect from light
    color pink to very dark purple
    solubility DMSO: 1 mg/mL (warmed)
    storage temp. −20°C
    InChI 1S/C40H52O4/c1-27(17-13-19-29(3)21-23-33-31(5)37(43)35(41)25-39(33,7)8)15-11-12-16-28(2)18-14-20-30(4)22-24-34-32(6)38(44)36(42)26-40(34,9)10/h11-24,35-36,41-42H,25-26H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,27-15+,28-16+,29-19+,30-20+/t35-,36-/m0/s1
    InChI key MQZIGYBFDRPAKN-UWFIBFSHSA-N

    General description

    Astaxanthin (AST) is a red dietary carotenoid. It is mainly found in aquatic animals and microalgae, such as Haematococcus pluvialis and Chlorella zofingiensis.[3]

    Application

    Astaxanthin has been used:
    • as an antioxidant to study its effect on Brachionus manjavacas (Rotifera) population growth[1]
    • to study its effects on the treatment of diabetic retinopathy.[1][2]
    • to investigate its role in restoring the expression of Nrf2 (nuclear factor erythroid 2 p45-related factor 2) and glutathione S-transferase P1 (GSTP1) through epigenetic modification in human prostate LNCaP cells.[3]

    Packaging

    50 mg in glass bottle

    Biochem/physiol Actions

    In vivo and in vitro studies propose that astaxanthin (AST) possesses health-promoting activities, signifying its potential use in the prevention of various diseases, such as cancers and Parkinson’s disease.[3] Due to its bright red colour, AST has been used as a food colorant in animal feeds.[2]

    Astaxanthin is a potent antioxidant with antiproliferative, neuroprotective and anti-inflammatory activity. Astaxanthin protects against oxidative stress, inhibiting NF-KB, suppressing pro-inflammatory genes and suppressing production of pro-inflammatory compounds nitric oxide, prostaglandin E2, TNF-α, and interleukin-1β. Astaxanthin′s protection of cells from oxidative stress generated by TNF-α and palmitate has been shown to ameliorate insulin resistance. Astaxanthin has also been shown to be an inhibitor of PPARγ.

    Safety Information

    RIDADR 
    NONH for all modes of transport
    WGK Germany 
    WGK 3
    Flash Point(F) 
    Not applicable
    Flash Point(C) 
    Not applicable