Apigenin 7-O-Glucuronide (hydrate), 1mg

SKU:
CAY-33754-1MG
  • $97.00

    • Description

    Apigenin 7-O-Glucuronide (hydrate), 1mg

    Product Description

    Apigenin 7-O-glucuronide is a flavonoid that has been found in J. sigillata and has diverse biological activities. It inhibits matrix metalloproteinase-3 (MMP-3), MMP-8, MMP-9, and MMP-13 (IC50s = 12.87, 22.39, 17.52, and 0.27 μM, respectively). Apigenin 7-O-glucuronide also inhibits protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and aldose reductase with IC50 values of 7.14, 62.96, and 107.1 µM, respectively. It inhibits LPS-induced production of nitric oxide, prostaglandin E2, and TNF-α in RAW 264.7 cells when used at a concentration of 100 µM. Apigenin 7-O-glucuronide (5 or 10 mg/kg) improves survival in a mouse model of septic shock induced by LPS.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-((5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl)oxy)tetrahydro-2H-pyran-2-carboxylic acid, hydrate
    Molecular Formula
    C21H18O11 • XH2O
    Formula Weight
    446.4
    Purity
    ≥95%
    Formulation
    A solid
    Solubility
    • DMF: 10 mg/ml
    • DMSO: 10 mg/ml
    • PBS (pH 7.2): 1 mg/ml
    λmax
    270, 335 nm
    SMILES
    O=C1C2=C(O)C=C(O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3O)O)O)C(O)=O)C=C2OC(C4=CC=C(C=C4)O)=C1.O
    InChi Code
    InChI=1S/C21H18O11.H2O/c22-9-3-1-8(2-4-9)13-7-12(24)15-11(23)5-10(6-14(15)31-13)30-21-18(27)16(25)17(26)19(32-21)20(28)29;/h1-7,16-19,21-23,25-27H,(H,28,29);1H2/t16-,17-,18+,19-,21+;/m0./s1
    InChi Key
    XODLIZARORJIDL-ZSESPEEFSA-N
    Origin
    Plant/Ixeris sonchifolia
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years