Apigenin, 25MG

SKU:
CAY-10010275-25mg
  • $61.00

    • Description

    Apigenin, 25MG

    Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 µM to improve renal function in a rat model of glomerulonephritis.1 CK2 inhibition by 20 µM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells.2 Apigenin at 5 µM is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.3

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
    CAS Number
    520-36-5
    Synonyms
    • Chamomile
    • Flavone
    • NSC 83244
    • Versulin
    Molecular Formula
    C15H10O5
    Formula Weight
    270.2
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 25 mg/ml
    • DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml
    • DMSO: 15 mg/ml
    • Ethanol: 0.3 mg/ml
    λmax
    212, 269, 334 nm
    SMILES
    Oc1ccc(cc1)c1cc(=O)c2c(O)cc(O)cc2o1
    InChi Code
    InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
    InChi Key
    KZNIFHPLKGYRTM-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Wet ice in continental US; may vary elsewhere
    Stability
    ≥ 4 years