Amantadine hydrochloride, 25G

SKU:
A1260-25G
  • $271.00

    • Description

    Amantadine hydrochloride 

    Synonym: 1-Adamantanamine hydrochloride, 1-Adamantylamine hydrochloride, 1-Aminoadamantane hydrochloride, NSC 83653, Tricyclo[3.3.1.13,7]decan-1-amine hydrochloride

    • CAS Number 665-66-7

       

    • Empirical Formula (Hill Notation) C10H17N · HCl

       

    • Molecular Weight 187.71

       

    •  Beilstein/REAXYS Number 4198854

       

    •  EC Number 211-560-2

       

    •  MDL number MFCD00074723

       

    •  PubChem Substance ID 24277882

       

    •  NACRES NA.77

    Properties

    Related Categories A-AM, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology,
    Cell Signaling and Neuroscience, Dopaminergics, Endo, Neuroscience, Neurotransmission, Neurotransmitters, Other Dopaminergics
    Quality Level 100
    solubility H2O: 50 mg/mL
     - ethanol: soluble
    originator Endo
    SMILES string Cl[H].[H][C@@]12C[C@@]3([H])C[C@@]([H])(C1)CC(N)(C2)C3
    InChI 1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H/t7-,8+,9-,10-;
    InChI key WOLHOYHSEKDWQH-SOVZANNPSA-N

    General description

    Amantadine hydrochloride {tricyclo-[3,3,1,1]- deean-l-amine hydrochloride is a drug, which has rimantadine hydrochloride as its analog.[1]

    Application

    Amantadine hydrochloride has been used:
    • to determine its effectiveness in reducing surgery-induced cognitive impairment[3]
    • to preincubate multipotent stem cells (MSCs), to investigate the cellular internalization pathway[4]
    • to determine whether amantadine-attenuated sepsis-induces neuroinflammation and dysfunction of learning and memory[5]
    • to preincubate primary cultured rat dental pulp stem cells (rDPSCs)
    • to determine the pathway of internalization[6]

    Packaging

    5, 25, 100 g in poly bottle

    Biochem/physiol Actions

    Amantadine hydrochloride is effective against influenza viruses both in vivo and in vitro.[1] It is considered as an antagonist of the N-methyl-D-aspartate (NMDA) type glutamate receptor. Amantadine plays an important role in the release of dopamine, preventing dopamine reuptake and blocking microglial activation and neuroinflammation.[2]

    Dopamine releaser used to treat Parkinsonism and drug-induced extrapyramidal reactions.

    Features and Benefits

    This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

    This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

    This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

    Legal Information

    LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

    Safety Information

    Symbol 
    GHS07
    Signal word 
    Warning
    Hazard statements 
    H302
    Precautionary statements 
    P301 + P312 + P330
    Personal Protective Equipment 
    dust mask type N95 (US), Eyeshields, Gloves
    RIDADR 
    NONH for all modes of transport
    WGK Germany 
    WGK 3
    RTECS 
    AU4375000
    Flash Point(F) 
    Not applicable
    Flash Point(C) 
    Not applicable