6-beta-Naltrexol (CRM), 1MG

SKU:
CAY-18790-1MG
  • $93.00

    • Description

    6β-Naltrexol (CRM)

    Product Description

    6β-Naltrexol (Item No. 18790) is a certified reference material that is structurally categorized as an opioid. It is the major metabolite of naltrexone (Item Nos. ISO60192 | 15520).1 Unlike naltrexone, which acts as a µ-receptor antagonist or inverse agonist, 6β-naltrexol is a neutral opioid antagonist.2 6β-Naltrexol binds the µ-opioid receptor more potently than naloxone (Item Nos. ISO60191 | 15594) or naltrexone (Kis = 94, 420, and 265 pM, respectively) but is ~100-fold less effective at blocking morphine-modulated pain in vivo, as assessed using the mouse hot plate test.3 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    Synonyms
    • 6β-hydroxy Naltrexone
    Technical Information
    Formal Name
    (5α,6β)-17-(cyclopropylmethyl)-4,5-epoxy-morphinan-3,6,14-triol
    CAS Number
    49625-89-0
    Molecular Formula
    C20H25NO4
    Formula Weight
    343.4
    Formulation(Request formulation change)
    A 1 mg/ml solution in methanol
    SMILES
    O[C@]12[C@]3(CCN(CC4CC4)[C@@H]2C5)[C@](OC6=C3C5=CC=C6O)([H])[C@H](O)CC1
    InChi Code
    InChI=1S/C20H25NO4/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11/h3-4,11,14-15,18,22-24H,1-2,5-10H2/t14-,15-,18+,19+,20-/m1/s1
    InChi Key
    JLVNEHKORQFVQJ-PYIJOLGTSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 2 years