2,6-Di-tert-butyl-4-methylphenol (GC), powder (500g)

SKU:
B1378-500G
  • $48.62

    • Description

    B1378 Sigma-Aldrich

    2,6-Di-tert-butyl-4-methylphenol

    ≥99.0% (GC), powder

    Synonym: 2,6-Di-tert-butyl-p-cresol, BHT, Butylated hydroxytoluene, Butylhydroxytoluene, DBPC

    • CAS Number 128-37-0

       

    • Linear Formula [(CH3)3C]2C6H2(CH3)OH

       

    • Molecular Weight 220.35

       

    •  Beilstein/REAXYS Number 1911640

       

    •  EC Number 204-881-4

       

    •  MDL number MFCD00011644

    Description

    Packaging

    1 kg in poly bottle

    100, 500 g in poly bottle

    Biochem/physiol Actions

    Butylated hydroxytoluene (BHT) is a phenolic antioxidant. It has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.

    Properties

    Related Categories Building Blocks, C9 to C20+, Chemical Synthesis, Organic Building Blocks, Oxygen Compounds,
    More...
    vapor density   7.6 (vs air)
    vapor pressure   <0.01 mmHg ( 20 °C)
    InChI Key   NLZUEZXRPGMBCV-UHFFFAOYSA-N
    assay   ≥99.0% (GC)
    form   powder
    autoignition temp.   878 °F
    bp   265 °C (lit.)
    mp   69-73 °C (lit.)
    solubility   ethanol: 100 mg/mL
      vegetable oils: soluble
    Gene Information   human ... CAPN1(823)
    rat ... Capn1(29153), Nos1(24598)