Description
Trifluorothymidine, ≥99% by HPLC, 100MG
Synonym(s):
α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine
Empirical Formula (Hill Notation):
C10H11F3N2O5
CAS Number:
70-00-8
Molecular Weight:
296.20
EC Number:
200-722-8
MDL number:
MFCD00006534
PubChem Substance ID:
24900027
NACRES:
NA.51
PROPERTIES
biological source
synthetic
Quality Level
100
assay
≥99% (HPLC)
form
powder
mp
190-193 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F
InChI
1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
InChI key
VSQQQLOSPVPRAZ-RRKCRQDMSA-N
DESCRIPTION
Application
Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells,[1] human lymphoblastoid TK6 cells,[2] and L5178Y mouse lymphoma cells.[3]
Biochem/physiol Actions
Trifluorothymidine is a thymidine analog[4] and is light sensitive.[1] TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics.[5] Incorporation of phosphorylated TFT into DNA induces damage,[6] making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase[5] and in screening mutant thymidine kinase gene.[1]. It elicits antitumor activity in gastrointestinal (GI) cancers[7] and has therapeutic potential to treat herpetic keratitis.[4]
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
SAFETY INFORMATION
Signal Word
Warning
Hazard Statements
H341 - H351 - H361d
Precautionary Statements
P201 - P202 - P280 - P308 + P313 - P405 - P501
Hazard Classifications
Carc. 2 - Muta. 2 - Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
-
MilliporeSigmagamma-Tocopherol (HPLC) (100mg)
SKU: T1782-100MG
$287.00T1782 Sigma-Aldrich (+)-γ-Tocopherol ≥96% (HPLC) Synonym: (R,R,R)-γ-Tocopherol, 7,8-Dimethyltocol, gamma-Tocopherol CAS Number 54-28-4 -
LGCFenhexamid, 100mg
SKU: DRE-C13476000
$144.00Fenhexamid, 100mg Product Code DRE-C13476000 CAS Number 126833-17-8 Product Format Neat Lot Number G1042132 Expiry 13/11/2023 Molecular Formula C14 H17 Cl2 N O2 Molecular Weight 302.20 -
LGCNaphthalene, 100mg
SKU: DRE-C20905000
$58.00Naphthalene, 100mg Synonyms: Naphthalene, Albocarbon, Dezodorator, Moth flakes, NSC 37565, Naphthene, Tar camphor, White tar Product Code DRE-C20905000 CAS Number 91-20-3 Product... -
LGCPhenolphthalein, 100MG
SKU: DRE-C16027000
$115.00Phenolphthalein, 100MG Synonyms: Phthalimetten, Koprol, Phthalin, Purgen, 3,3-bis(4-hydroxyphenyl)isobenzofuran-1(3H)-one, 1(3H)-Isobenzofuranone, 3,3-bis(4-hydroxyphenyl)-, Laxogen, TY 9,... -
LGCPropaquizafop, 100mg
SKU: DRE-C16425000
$101.00Propaquizafop, 100mg Controlled product. We may require documentation to meet relevant regulations. Product Code DRE-C16425000 CAS Number 111479-05-1 Product Format < -
Cayman Chemical Co.Captan, 100MG
SKU: CAY-24138-100MG
$61.00Captan, 100MG Technical Information Formal Name 3a,4,7,7a-tetrahydro-2-[(trichloromethyl)thio]-1H-isoindole-1,3(2H)-dione CAS Number 133-06-2 Synonyms NSC 36726 Molecular Formula -
Cayman Chemical Co.Boscalid, 100MG
SKU: CAY-24135-100MG
$74.00Boscalid Boscalid is a broad-spectrum carboxamide fungicide that inhibits fungal respiration by binding to the ubiquinone site of mitochondrial complex II/succinate dehydrogenase.1 It suppresses... -
LGCCarbazole, 100mg
SKU: DRE-C10985000
$58.00Carbazole, 100mg Synonyms: 9H-Carbazole, 9-Azafluorene, Chlorophenesin carbamate, Dibenzo[b,d]pyrrole, Dibenzopyrrole, Diphenylenimine, NSC 3498, SKF 20091, Carprofen Related Compound... -
LGCFluoxetine, 100MG
SKU: TRC-F597183-100MG
$129.00Fluoxetine, 100MG Synonyms: Benzenepropanamine, N-methyl-γ-[4-(trifluoromethyl)phenoxy]-, Benzenepropanamine, N-methyl-γ-[4-(trifluoromethyl)phenoxy]-, (±)-,...
