Trifluoroacetic acid for synthesis, 1L

SKU:
8082601001
  • $490.00

    • Description

    Trifluoroacetic acid for synthesis, 1L

    for synthesis

    Synonym(s):
    TFA
    Linear Formula:
    CF3COOH
    CAS Number:
    76-05-1
    Molecular Weight:
    114.02
    Beilstein:
    742035
    MDL number:
    MFCD00004169
    EC Index Number:
    200-929-3

    PROPERTIES

    vapor density

    3.9 (vs air)

    Quality Level

    200

    vapor pressure

    97.5 mmHg ( 20 °C)

    Assay

    ≥99% (acidimetric)

    form

    liquid

    refractive index

    n20/D 1.3 (lit.)

    pH

    1 (10 g/L in H2O)

    bp

    72.4 °C (lit.)

    mp

    −15.4 °C (lit.)

    solubility

    soluble 10 g/mL

    density

    1.489 g/mL at 20 °C (lit.)

    storage temp.

    2-30°C

    SMILES string

    OC(C(F)(F)F)=O

    InChI

    1S/C2HF3O2/c3-2(4,5)1(6)7/h(H,6,7)

    InChI key

    DTQVDTLACAAQTR-UHFFFAOYSA-N

    DESCRIPTION

    General description

    Trifluoroacetic acid is widely used in organic synthesis as a solvent, catalyst and reagent. It is a strong acid and low boiling point reagent. It can be used as a catalyst for a variety of reactions such as rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.[1]

    Application

    Trifluoroacetic acid can be used as a catalyst

    • In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
    • In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.
    Trifluoroacetic acid can also be used
    • In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.

    Packaging

    1 l in Glass bottle
    25 , 500 ml in Glass bottle
    2.5 l
    100 ml
    25 kg in Barrel PE/met

    Features and Benefits

    Trifluoroacetic acid can be used as a catalyst due to its
    • High acidity
    • Easy elimination
    • Good solubility in organic solvent and in water.

    Analysis Note

    Assay (acidimetric): ≥ 99.0 %
    Density (d 20 °C/ 4 °C): 1.487 - 1.490
    Identity (IR): passes test

    SAFETY INFORMATION

    Signal Word

    Danger

    Hazard Statements

    H314 - H332 - H412

    Precautionary Statements

    P261 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

    Hazard Classifications

    Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

    Storage Class Code

    8A - Combustible, corrosive hazardous materials

    WGK

    WGK 2

    Flash Point(F)

    212.0 °F - Pensky-Martens closed cup

    Flash Point(C)

    > 100 °C - Pensky-Martens closed cup