Ribozinoindole-1

SKU:
CAY-20745-1MG
  • $93.00

    • Description

    Ribozinoindole-1

    Technical Information
    Formal Name
    3-[(2-methyl-2-propen-1-yl)thio]-5H-1,2,4-triazino[5,6-b]indole
    CAS Number
    328023-11-6
    Synonyms
    • Ribozinoindole-1
    Molecular Formula
    C13H12N4S
    Formula Weight
    256.3
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    SolubilityDMF: 5 mg/ml
    • DMSO: 25 mg/ml
    λmax
    224, 266, 346 nm
    SMILES
    C=C(C)CSC(N=N1)=NC2=C1C3=CC=CC=C3N2
    InChi Code
    InChI=1S/C13H12N4S/c1-8(2)7-18-13-15-12-11(16-17-13)9-5-3-4-6-10(9)14-12/h3-6H,1,7H2,2H3,(H,14,15,17)
    InChi Key
    LPCWHNSRTRBKBO-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years

    Rbin-1 is a triazinoindole inhibitor of midasin (mdn1), an essential protein for eukaryotic ribosome biogenesis.1 It inhibits the growth of fission yeast strains in vitro (GI50 = 136 nM) and inhibits mdn1 ATPase activity by approximately 40% when used at a concentration of 1 µM. Rbin-1 inhibits pre-rRNA processing and nuclear export of the pre-60S ribosome subunit in mdn1-ts, but not mdn1-F1093L mutant, S. pombe cells. It also decreases ribosome assembly protein 4 (Rsa4) levels in Rix1 particles, a ribosome assembly intermediate, Rix1-bound Ytm1 levels, and Rix7 and Ppp1 levels in the nucleolar pre-60S particle Nsa1 in mdn1-ts fission yeast cells.

    WARNING This product is not for human or veterinary use.