Stable Isotope Pesticide Standards

To determine matrix effects and result bias due to a loss of the analyte during the workup process, isotope dilution mass spectrometry is often applied. This technique takes advantage of the fact that isotope labeled compounds have nearly the same physical properties as the nonlabeled analogues and thus the same behavior in the workup and sample preparation process. However, they can be distinguished in mass spectrometry. Therefore, by spiking the sample before workup with an isotope labeled analogue, material loss during workup can be determined and compensated.