Description
Periodic acid, for synthesis, >98% 500g
Synonym(s):
Periodic acid
Empirical Formula (Hill Notation):
H5IO6
CAS Number:
10450-60-9
Molecular Weight:
227.94
MDL number:
MFCD00011344
EC Index Number:
233-937-0
PROPERTIES
Quality Level
200
assay
≥98% (iodometric)
form
solid
reaction suitability
reagent type: oxidant
pH
1.2 (20 °C, 100 g/L in H2O)
mp
122 °C
solubility
ethanol: soluble at 20 °C
water: soluble at 20 °C
bulk density
1400 kg/m3
storage temp.
15-25°C
InChI
1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
InChI key
TWLXDPFBEPBAQB-UHFFFAOYSA-N
DESCRIPTION
Application
Periodic acid can be used as a reagent for the oxidative cleavage of 1,2 diols to ketones or aldehydes, and epoxides to aldehydes. It is also used in the oxidative cleavage of various protecting groups such as acetonide, tetrahydropyranyl ether (THP), ethoxyethyl acetals, cyclic acetals, dithioacetals, and oxathioacetals.
It can also be used:
It can also be used:
- In the selective N-nitrosation of secondary amines in the presence of sodium nitrite, and wet silica gel.
- As a stoichiometric oxidant with chromium (IV) acetate for the oxidation of tertiary C−H bonds to tertiary alcohols.
- In combination with chromium oxide to oxidize primary alcohols to carboxylic acids; alkylbenzenes to benzoic acids; and cyclic benzyl ethers to the corresponding lactones.
- In the iodination of bulky polyalkyl benzenes in the presence of iodine.
- In the oxidative coupling of polycyclic aromatic hydrocarbons in the presence of aqueous acetic acid.
- In the selective oxidation of sulfides to sulfoxides using FeCl3 as a catalyst.
Analysis Note
Assay (iodometric): ≥ 98.0 %
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C
Melting range (lower value): ≥ 124 °C
Melting range (upper value): ≤ 129 °C
SAFETY INFORMATION
Signal Word
Danger
Hazard Statements
H271 - H314 - H372 - H400
Precautionary Statements
P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Classifications
Aquatic Acute 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
Target Organs
Thyroid
Storage Class Code
5.1A - Strongly oxidizing hazardous materials
WGK
WGK 3