Mesembrine, 1mg

SKU:
CAY-21100-1MG
  • $155.00

    • Description

    Mesembrine, 1mg

    Item No. 21100

    Technical Information
    Formal Name
    (3aS,7aS)-3a-(3,4-dimethoxyphenyl)octahydro-1-methyl-6H-indol-6-one
    CAS Number
    24880-43-1
    Synonyms
    • Mesembranone
    • (–)-Mesembrine
    Molecular Formula
    C17H23NO3
    Formula Weight
    289.4
    Purity
    ≥98%
    Formulation(Request formulation change)
    A solution in ethanol
    Solubility
    • Chloroform: 10 mg/ml
    • Ethanol: 10 mg/ml
    SMILES
    COC1=CC=C([C@]2(CCN3C)[C@]3([H])CC(CC2)=O)C=C1OC
    InChi Code
    InChI=1S/C17H23NO3/c1-18-9-8-17(7-6-13(19)11-16(17)18)12-4-5-14(20-2)15(10-12)21-3/h4-5,10,16H,6-9,11H2,1-3H3/t16-,17-/m0/s1
    InChi Key
    DAHIQPJTGIHDGO-IRXDYDNUSA-N
    Origin
    Plant/Sceletium tortuosum
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Wet ice in continental US; may vary elsewhere
    Stability
    ≥ 2 years
    Product Description

    Mesembrine is an alkaloid that has been found in S. tortuosum and has serotonin (5-HT) reuptake inhibitory activity.1 It selectively binds to the 5-HT transporter (SERT; IC50 = 4.3 µg/ml) over a variety of receptors (IC50s = 148->750 µg/ml).2 Mesembrine inhibits the reuptake of 5-HT in vitro (Ki = 1.4 nM). It has analgesic effects in the hot plate test when administered at a dose of 20 mg/kg but does not induce a preference in the conditioned place preference test (CPP).2,3

    WARNING This product is not for human or veterinary use.