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Melatonin, Pharmaceutical Secondary Standard; Certified Reference Material, 500MG

SKU:
PHR1767-500MG
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    • Description

    Melatonin, Pharmaceutical Secondary Standard; Certified Reference Material, 500MG

    Synonym(s):
    Melatonin, N-Acetyl-5-methoxytryptamine
    Empirical Formula (Hill Notation):
    C13H16N2O2
    CAS Number:
    73-31-4
    Molecular Weight:
    232.28
    Beilstein:
    205542
    EC Number:
    200-797-7
    MDL number:
    MFCD00005655
    PubChem Substance ID:
    329823599
    NACRES:
    NA.24

    PROPERTIES

    grade

    certified reference material
    pharmaceutical secondary standard

    Quality Level

    300

    Agency

    traceable to BP 1077
    traceable to USP 1380105

    form

    solid

    CofA

    current certificate can be downloaded

    packaging

    pkg of 500 mg

    technique(s)

    HPLC: suitable
    gas chromatography (GC): suitable

    mp

    116.5-118 °C (lit.)

    application(s)

    pharmaceutical (small molecule)

    storage temp.

    2-8°C

    SMILES string

    COc1ccc2[nH]cc(CCNC(C)=O)c2c1

    InChI

    1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)

    InChI key

    DRLFMBDRBRZALE-UHFFFAOYSA-N

    General description

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. It is analyzed using GMP validated instruments as per pharmacopeia monograph methods and is traceable to Unites States Pharmacopeia (USP), European Pharmacopeia (EP), and British Pharmacopeia (BP) primary standards, wherever applicable. It is provided with a comprehensive certificate of analysis (CoA) containing a certified purity value, calculated by the mass balance approach.
    All information regarding the use of this CRM can be found on the certificate of analysis.

    Melatonin is a methoxyindole compound secreted by the pineal gland in the mammalian brain. It regulates the sleep-wake cycles (circadian rhythm) and also has anti-inflammatory and antioxidant properties.

    Application

    Melatonin pharmaceutical reference standard may also be used as follows:
    • Development and validation of a high-performance liquid chromatography (HPLC) method combined with UV detection to determine melatonin in capsule dosage forms
    • Determination of melatonin in dog plasma samples by liquid chromatography-tandem mass spectrometry (LC-MS/MS) method
    • Simultaneous electrochemical analysis of melatonin and 5-hydroxytryptophan by poly-(melamine)/poly-(o-aminophenol) modified screen printed electrodes (SPCs) in human urine samples
    • Determination of melatonin in pharmaceutical formulations by voltammetric and amperometric methods using carbon black modified glassy carbon electrode
    • Electroanalytical determination of melatonin in tablet and human urine samples using a boron-doped diamond electrode and square-wave voltammetry (SWV)
    • Development of nanopalladium polymeric nanocomposite modified glassy carbon electrode (GCE) for qualitative and quantitative analyses of melatonin in tablets and human urine samples by square-wave voltammetry
    • Liquid chromatography-diode array detection (LC-DAD) of melatonin dose in supplements and also detection of impurities present in supplements by ultra-high-performance liquid chromatography-orbitrap mass spectrometry (UHPLC-orbitrap-MS)

    Other Notes

    Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

    Footnote

    To see an example of a Certificate of Analysis for this material enter LRAA8251 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

    SAFETY INFORMATION

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 2

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable