Lamotrigine-d3

SKU:
CAY-37196-1MG
  • $210.00

    • Description

    Lamotrigine-d3

    Lamotrigine-d3 is intended for use as an internal standard for the quantification of lamotrigine (Item No. 15428) by GC- or LC-MS. Lamotrigine is an anticonvulsant.1 It inhibits voltage-gated sodium channels (Nav) in HEK293 cells expressing recombinant human Nav1.2, Nav1.5, or Nav1.8 (IC50s = 10, 62, and 96 μM, respectively), as well as high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by the N-type calcium channel blocker ω-conotoxin GVIA (Item No. 24114) and P-type calcium channel blocker ω-agatoxin IVA (Item No. 21605).1,2 Lamotrigine protects against seizures induced by maximal electroshock (MES) in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively).3 It also decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg).1 Formulations containing lamotrigine have been used in the treatment of epilepsy and bipolar disorder.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    6-(5,6-dichlorophenyl-2,3,4-d3)-1,2,4-triazine-3,5-diamine
    CAS Number
    1132746-94-1
    Synonyms
    • LTG-d3
    Molecular Formula
    C9H4Cl2D3N5
    Formula Weight
    259.1
    Purity
    ≥99% deuterated forms (d1-d3)
    Formulation(Request formulation change)
    A solid
    Solubility(Learn about Variance in Solubility)
    • DMF: 10 mg/ml
    • DMSO: 10 mg/ml
    • DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
    • Ethanol: 2 mg/ml
    SMILES
    NC1=NC(N)=NN=C1C2=C(C(Cl)=C([2H])C([2H])=C2[2H])Cl
    InChi Code
    InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)/i1D,2D,3D
    InChi Key
    PYZRQGJRPPTADH-CBYSEHNBSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years