Kainic acid monohydrate, 10MG

SKU:
K0250-10MG
  • $261.00

    • Description

    Kainic acid monohydrate, ≥99% (TLC), 10MG

    Synonym(s):
    2-Carboxy-3-carboxymethyl-4-isopropenylpyrrolidine
    Empirical Formula (Hill Notation):
    C10H15NO4 · H2O
    CAS Number:
    58002-62-3
    Molecular Weight:
    231.25
    MDL number:
    MFCD00150833
    PubChem Substance ID:
    24277985
    NACRES:
    NA.77

    Quality Level

    100

    assay

    ≥99% (TLC)

    form

    powder

    impurities

    Glutamate, free

    solubility

    H2O: soluble

    storage temp.

    2-8°C

    SMILES string

    O.CC(=C)[C@H]1CN[C@@H]([C@H]1CC(O)=O)C(O)=O

    InChI

    1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9-;/m0./s1

    InChI key

    FZNZRJRSYLQHLT-SLGZUKMRSA-N

    Gene Information

    human ... GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK4(2900) , GRIK5(2901) , SLC1A1(6505) , SLC1A2(6506) , SLC1A3(6507)
    mouse ... Gria1(14799)
    rat ... Gria1(50592) , Grik1(29559) , Grik4(24406) , Grin2a(24409)

    General description

    Kainic acid is an agonist for kainate-class ionotropic glutamate receptors. Kainate receptors directly gate ion channels and are generally excitatory. Excess stimulation by Kainic acid induces neurocytosis (apoptosis) and epileptic seizures.

    Packaging

    10, 50 mg in glass insert

    Application

    Kainic acid is used to study mechanisms of excitation-induced apoptosis and epilepsy.

    Biochem/physiol Actions

    Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.

    Features and Benefits

    This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
    This compound is featured on the Excitatory Amino Acid Transporters and Glutamate Receptors (Ion Channel Family) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

    Preparation Note

    Dissolve in 1-2 drops of 1N NaOH then bring to volume with water or aqueous buffer. Can be stored 1-2 days refrigerated.

    SAFETY INFORMATION

    Storage Class Code

    13 - Non Combustible Solids

    WGK

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves