Kainic Acid (hydrate), 5MG

SKU:
CAY-78050-5MG
  • $72.00

    • Description

    (−)-(α)-Kainic Acid (hydrate), 5MG

    Product Description

    (−)-(α)-Kainic acid is a cyclic analog of L-glutamate originally isolated from D. simplex that has neuroexcitatory activities.1 It binds to the homomeric kainate receptors GluK1, GluK2, GluK3, GluK4, and GluK5 (Kis = 75.9, 12.7, 32.8, 4.7, and 15 nM, respectively).2 (−)-(α)-Kainic acid (5 mM) induces calcium influx and membrane depolarization, as well as glutamate release, in rat brain synaptosomes.3 It induces chromatin condensation and nuclear membrane fragmentation, markers of apoptosis, in primary neonatal cerebellar granule neurons when used at a concentration of 100 µM.4 Intracerebroventricular administration of (−)-(α)-kainic acid induces convulsive behavior in rats (ED50 = 0.51 nmol/animal) and induces seizures in mice with a 50% convulsive dose (CD50) value of 0.39 nmol/animal.5 It has been commonly used to induce seizures in rodents.6,7

    WARNING This product is not for human or veterinary use.

    echnical Information
    Formal Name
    2S-carboxy-4S-(1-methylethenyl)-3S-pyrrolidineacetic acid, monohydrate
    CAS Number
    58002-62-3
    Molecular Formula
    C10H15NO4 • H2O
    Formula Weight
    231.2
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • PBS (pH 7.2): 50 mg/ml
    SMILES
    [H]N1C[C@H](C(C)=C)[C@H](CC(O)=O)[C@H]1C(O)=O.O
    InChi Code
    InChI=1S/C10H15NO4.H2O/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13;/h6-7,9,11H,1,3-4H2,2H3,(H,12,13)(H,14,15);1H2/t6-,7+,9?;/m0./s1
    InChi Key
    FZNZRJRSYLQHLT-AQLFBIHGSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years