Hexamethyldisilazane, 250mL

SKU:
52619-250ML
  • $317.00

    • Description

    Hexamethyldisilazane 

    for GC derivatization, LiChropur™, ≥99.0% (GC)

    Synonym(s):
    HMDS
    Linear Formula:
    (CH3)3SiNHSi(CH3)3
    CAS Number:
    999-97-3
    Molecular Weight:
    161.39
    Beilstein:
    635752
    EC Number:
    213-668-5
    MDL number:
    MFCD00008259
    PubChem Substance ID:
    329757861

    PROPERTIES

    grade

    for GC derivatization

    Quality Level

    100

    Assay

    ≥99.0% (GC)

    form

    liquid

    quality

    LiChropur™

    reaction suitability

    reagent type: derivatization reagent
    reaction type: Silylations

    technique(s)

    gas chromatography (GC): suitable

    refractive index

    n20/D 1.407 (lit.)
    n20/D 1.408

    bp

    125 °C (lit.)

    SMILES string

    C[Si](C)(C)N[Si](C)(C)C

    InChI

    1S/C6H19NSi2/c1-8(2,3)7-9(4,5)6/h7H,1-6H3

    InChI key

    FFUAGWLWBBFQJT-UHFFFAOYSA-N

    DESCRIPTION

    General description

    Hexamethyldisilazane (HMDS) is a commercially available, silylating agent,[1][2] which is used as an alternative for the preparation of silyl ethers from hydroxyl compounds.[2]

    Application

    Learn more in the Product Information
    Hexamethyldisilazane is suitable for the derivatization of alcohols, U-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

    It may be used as a derivatizing reagent for the analysis of bioamines and their acidic metabolites,[3] phenol, hydroquinone and catechol[4] in urine samples, mixtures of free fatty acids and metal soaps in paint samples[5] using gas chromatography/mass spectrometry (GC/MS).
    Suitable for the derivatization of alcohols, Υ-aminobutyric acid, pesticidal carbamates and urea, 3,4-Dihydroxyphenylglycol, 4-hydroxycoumarins, hydroxyfatty acids, n-hydroxy-2-fluorenylacetamide, kerb cycle acid, malonaldehyde, monoglycerides, phenylpyruvic acid, shikimic acid, unsaturated fatty acid esters (or methyl esters), and related compounds.

    Features and Benefits

    • HMDS is inexpensive and has a relatively low boiling point (124-127 °C).
    • It can be used without solvent but its silylating power can be increased by various (mostly acidic) catalysts.
    • The only reaction byproduct, ammonia, can leave the reaction mixture as the reaction goes to completion.

    Other Notes

    Important silylating agent[6][7]
    Reagent for 2-hydroxypyrimidine, polytrimethylsilyloxy, trimethylsilyl and trimethylsilyl oximes.

    Legal Information

    LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

    SAFETY INFORMATION

    Signal Word

    Danger

    Hazard Statements

    H225 - H302 + H332 - H311 - H412

    Precautionary Statements

    P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312

    Hazard Classifications

    Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Flam. Liq. 2

    Storage Class Code

    3 - Flammable liquids

    WGK

    WGK 2

    Flash Point(F)

    52.5 °F - closed cup

    Flash Point(C)

    11.4 °C - closed cup

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves