Ganoderic Acid DM, Item No. 34536, 1mg

SKU:
CAY-34536-1mg
  • $110.00

    • Description

    Ganoderic Acid DM

    Item No. 34536

    Technical Information
    Formal Name
    3,7-dioxo-lanosta-8,24E-dien-26-oic acid
    CAS Number
    173075-45-1
    Molecular Formula
    C30H44O4
    Formula Weight
    468.7
    Purity
    ≥98%
    Formulation
    A solid
    Solubility
    • Methanol: soluble
    λmax
    217, 251 nm
    SMILES
    C[C@]12C3=C(CC[C@@]1([C@]([C@@H](CC/C=C(C)/C(O)=O)C)([H])CC2)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C
    InChi Code
    InChI=1S/C30H44O4/c1-18(9-8-10-19(2)26(33)34)20-11-16-30(7)25-21(12-15-29(20,30)6)28(5)14-13-24(32)27(3,4)23(28)17-22(25)31/h10,18,20,23H,8-9,11-17H2,1-7H3,(H,33,34)/b19-10+/t18-,20-,23+,28-,29-,30+/m1/s1
    InChi Key
    ZTKZZRIVAYGFSF-PIPDTRPPSA-N
    Origin
    Plant/Unspecified sp.
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Ganoderic acid DM is a triterpenoid that has been found in G. lucidum and has diverse biological activities. 1,2,3 It inhibits 5α-reductase and HMG-CoA reductase (IC50s = 10.6 and 9.5 µM, respectively) and binds to the ligand-binding domain of the androgen receptor in a fluorescence polarization assay.1,2 Ganoderic acid suppresses osteoclastogenesis of RAW 264.7 cells when used at a concentration of 12.5 µM and is cytotoxic to K562 leukemia and PC3 prostate cancer cells (IC50s = 18.8 and 81.6 µM, respectively). It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice (ID50 = 0.08 mg/ear).3

    WARNING This product is not for human or veterinary use.