Ganoderic Acid D

SKU:
CAY-26765-1MG
  • $37.00

    • Description

    Ganoderic Acid D

    Ganoderic acid D is an oxygenated triterpenoid that has been found in G. lucidum.1 It inhibits glucose uptake and lactate production when used at concentrations ranging from 50 to 200 µM and decreases pyruvate and acetyl-coenzyme A production at concentrations of 100 and 200 µM in HT-29 and SW620 colon cancer cells. Ganoderic acid D increases protein levels of sirtuin 3 (SIRT3) in HT-29 and SW620 cells. It is cytotoxic to HepG2, HeLa, and Caco-2 cells with IC50 values of 0.14, 0.18, and 0.02 µg/ml, respectively.2

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    7β-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid
    CAS Number
    108340-60-9
    Molecular Formula
    C30H42O7
    Formula Weight
    514.7
    Purity
    ≥97%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 30 mg/ml
    • DMSO: 30 mg/ml
    • Ethanol: 30 mg/ml
    • Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml
    λmax
    254 nm
    SMILES
    O=C1CC[C@@]2(C)[C@](C[C@H](O)C([C@@](C(C[C@]3([H])[C@H](C)CC(CC(C)C(O)=O)=O)=O)(C)[C@]3(C)C4)=C2C4=O)([H])C1(C)C
    InChi Code
    InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16?,18-,19+,21+,28+,29-,30+/m1/s1
    InChi Key
    YTVGSCZIHGRVAV-IYAQLQCNSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years