Ganoderic Acid C1, Item No. 33212, 1mg

SKU:
CAY-33212-1mg
  • $81.00

    • Description

    Ganoderic Acid C1

    Item No. 33212

    Technical Information
    Formal Name
    (7β,25R)-7-hydroxy-3,11,15,23-tetraoxo-lanost-8-en-26-oic acid
    CAS Number
    95311-97-0
    Molecular Formula
    C30H42O7
    Formula Weight
    514.7
    Purity
    ≥98%
    Formulation
    A crystalline solid
    Solubility
    • DMSO: soluble
    λmax
    253 nm
    SMILES
    C[C@]12C3=C(C(C[C@@]1([C@]([C@@H](CC(C[C@@H](C)C(O)=O)=O)C)([H])CC2=O)C)=O)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])C[C@@H]3O)C
    InChi Code
    InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h15-16,18-19,21,32H,8-14H2,1-7H3,(H,36,37)/t15-,16-,18-,19+,21+,28+,29-,30+/m1/s1
    InChi Key
    YTVGSCZIHGRVAV-NJNFCIENSA-N
    Origin
    Fungi/Ganoderma lucidum
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Ganoderic acid C1 is a triterpenoid that has been found in G. lucidum and has diverse biological activities.1,2,3,4 It inhibits angiotensin-converting enzyme (ACE; IC50 = 745 µM).2 Ganoderic acid C1 also inhibits HIV-1 protease with an IC50 value of 180 µM.1 It reduces the proliferation of murine Lewis lung carcinoma cells but not murine Meth-A sarcoma cells (EC50s = 17 and >20 µg/ml, respectively).3 Ganoderic acid C1 (20 µg/ml) inhibits LPS-induced NF-κB phosphorylation and production of TNF-α in RAW 264.7 cells, as well as in peripheral blood mononuclear cells (PBMCs) isolated from patients with asthma.4

    WARNING This product is not for human or veterinary use.