Dihydromethysticin, 5MG

SKU:
CAY-27644-5MG
  • $238.00

    • Description

    Dihydromethysticin, 5MG

    Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties.1,2 Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM (Item No. 14948) by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM.3 Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice.1 It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    (6S)-6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one
    CAS Number
    19902-91-1
    Synonyms
    • NSC 112159
    Molecular Formula
    C15H16O5
    Formula Weight
    276.3
    Purity
    ≥98%
    Formulation(Request formulation change)
    A solid
    Solubility
    Chloroform: soluble
    • Methanol: soluble
    SMILES
    O=C1O[C@@H](CCC2=CC=C(OCO3)C3=C2)CC(OC)=C1
    InChi Code
    InChI=1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1
    InChi Key
    RSIWXFIBHXYNFM-NSHDSACASA-N
    Origin
    Synthetic
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years

    Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties.1,2 Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM (Item No. 14948) by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM.3 Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice.1 It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.2

    WARNING This product is not for human or veterinary use.