Chlortetracycline Hydrochloride, 25G

SKU:
C4881-25G
  • $152.00

    • Description

    Chlortetracycline hydrochloride

    ≥91.0% dry basis (HPLC)

    7-Chlorotetracycline hydrochloride
    Empirical Formula (Hill Notation):
    C22H23ClN2O8 · HCl
    CAS Number:
    64-72-2
    Molecular Weight:
    515.34
    Beilstein:
    3858364
    EC Number:
    200-591-7
    MDL number:
    MFCD00082440
    PubChem Substance ID:
    24892735
    NACRES:
    NA.85

    PROPERTIES

    Quality Level

    200

    Assay

    ≥91.0% dry basis (HPLC)

    form

    powder

    pKa (25 °C)

    3.3
    7.4
    9.3

    mp

    210-215 °C (dec.) (lit.)

    solubility

    1 M NaOH: 50 mg/mL

    antibiotic activity spectrum

    Gram-negative bacteria
    Gram-positive bacteria

    Mode of action

    protein synthesis | interferes

    storage temp.

    −20°C

    SMILES string

    Cl.CN(C)[C@H]1[C@@H]2CC3C(=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O

    InChI

    1S/C22H23ClN2O8.ClH/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21;/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31);1H/t7?,8-,15-,21-,22-;/m0./s1

    InChI key

    CBHYYLPALVVVEY-LYNLVHCPSA-N

    General description

    Chemical structure: tetracycline

    Application

    Chlortetracycline was used in fluorescence assays to detect the Ca+2 influx required for the completion of acrosome reaction in human spermatozoa.[1][2]

    Biochem/physiol Actions

    Chlortetracycline is an antibiotic produced by some strains of Streptomyces aureofaciens. It inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. It is effective against Gram-positive and to a lesser degree Gram-negative bacteria than tetracycline.
    Mode of Resistance: Loss of cell wall permeability.

    Other Notes

    If stored frozen, chlortetracycline hydrochloride is expected to remain stable at least four years.

    SAFETY INFORMATION

    Pictograms

    GHS07,GHS08

    Signal Word

    Warning

    Hazard Statements

    H315 - H317 - H319 - H335 - H361fd

    Precautionary Statements

    P202 - P261 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313

    Hazard Classifications

    Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

    Target Organs

    Respiratory system

    Storage Class Code

    11 - Combustible Solids

    WGK

    WGK 2

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable

    Personal Protective Equipment

    dust mask type N95 (US), Eyeshields, Gloves