Description
c-di-AMP sodium salt ≥98% (HPLC)
Synonym: 3′,5′-Cyclic diadenylic acid sodium salt, Adenylyl-(3′5′)-3′-adenylic acid, cyclic nucleotide sodium salt, Cyclic di-3′,5′-adenylate sodium salt, Cyclic diadenylate monophosphate sodium salt, Cyclic diadenylate sodium salt, Cyclic-di-AMP sodium salt
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CAS Number 54447-84-6 (free acid)
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Empirical Formula (Hill Notation) C20H24N10O12P2 · xNa+
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Molecular Weight 658.41 (free acid basis)
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PubChem Substance ID 329825734
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NACRES NA.77
Properties
Related Categories | A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cyclic Nucleotide Metabolism, Cyclic Nucleotides and Analogs, G Proteins and Cyclic Nucleotides, Immune Cell Signaling and Blood, Immune System Regulation, Immunomodulators and Antibiotics |
Quality Level | 100 |
description | contains 1μmol of powder (approx. 0.7mg) |
assay | ≥98% (HPLC) |
form | powder |
color | white to beige |
storage temp. | −20°C |
SMILES string | NC1=NC=NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP(OC[C@@H]4[C@@H](O5)[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O4)(O)=O)[C@H]3COP5(O)=O.C |
Biochem/physiol Actions
It has a role in various signaling pathways. In Gram-positive bacteria, it influences cell growth and survival and modulates virulence. c-di-AMP is formed by diadenylate cyclases (DACs), which are cyclase domain-containing proteins.[1]
c-di-AMP is a bacterial secondary messenger. c-di-AMP acts as a potent mucosal adjuvant stimulating both humoral and cellular responses.
Preparation Note
c-di-AMP is soluble in water (≥ 16 mM, limits have not been determined).