Description
Application
The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
(2-Hydroxypropyl)-β-cyclodextrin is a β-cyclodextrin derivative with enhanced water solubility. It is used as a solubilizer and stabilizer in pharmaceutical formulations. HP-β-CD also shows potent anticancer activity.
Legal Information
Cavasol is a registered trademark of Wacker Chemie AG
Specifications:
Appearance (Color) | White to Off White |
Appearance (Form) | Powder or Crystals |
Loss on Drying | ≤ 7.0 % |
Residue on Ignition | ≤ 2.5 % |
Infrared Spectrum | CONFORMS TO STRUCTURE |
Inpurities A, B and C | Polypropyeneglycol ≤ 5.0 % |
Impurity E | Unsubstituted Cyclodextrine ≤ 1.0 % |
Molar Substitution | Molar Substitution 0.6 - 0.9 |