Ziprasidone-d₈

Ziprasidone-d₈ is intended for use as an internal standard for the quantification of ziprasidone (Item No. 15031) by GC- or LC-MS. Ziprasidone is an atypical antipsychotic.¹ It is an agonist of the serotonin (5-HT) receptor subtype 5-HT_1A (EC₅₀ = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT_1D receptors (IC₅₀ = 2.69 nM) and a partial agonist of 5-HT_1B receptors (EC₅₀ = 6.17 nM) in [³⁵S]GTPγS binding assays.^2,3 Ziprasidone is an antagonist at 5-HT_2A and dopamine D₂ receptors (K_is = 1.15 and 1.29 nM, respectively) in cell-based assays.⁴ It inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID₅₀s = 1.53 and 2.43 mg/kg, respectively). Formulations containing ziprasidone have been used in the treatment of schizophrenia and bipolar I disorder.

WARNING This product is not for human or veterinary use.