Ziprasidone-d8

SKU:
CAY-30737-1MG
  • $291.00

    • Description

    Ziprasidone-d8

    Ziprasidone-d8 is intended for use as an internal standard for the quantification of ziprasidone (Item No. 15031) by GC- or LC-MS. Ziprasidone is an atypical antipsychotic.1 It is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A (EC50 = 36.31 nM for inhibition of forskolin-induced adenylate cyclase activity in HeLa cells expressing human receptors), as well as an inverse agonist of 5-HT1D receptors (IC50 = 2.69 nM) and a partial agonist of 5-HT1B receptors (EC50 = 6.17 nM) in [35S]GTPγS binding assays.2,3 Ziprasidone is an antagonist at 5-HT2A and dopamine D2 receptors (Kis = 1.15 and 1.29 nM, respectively) in cell-based assays.4 It inhibits d-amphetamine-induced hyperactivity and apomorphine-induced stereotypy in rats (ID50s = 1.53 and 2.43 mg/kg, respectively). Formulations containing ziprasidone have been used in the treatment of schizophrenia and bipolar I disorder.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    5-[2-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl-2,2,3,3,5,5,6,6-d8]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one
    CAS Number
    1126745-58-1
    Synonyms
    • CP-88,059-d8
    Molecular Formula
    C21H13D8ClN4OS
    Formula Weight
    421.0
    Purity
    ≥99% deuterated forms (d1-d8)
    Formulation(Request formulation change)
    A solid
    Solubility
    • DMSO: slightly soluble
    • Methanol: slightly soluble
    SMILES
    [2H]C(C([2H])([2H])N(CCC1=C(Cl)C=C(NC(C2)=O)C2=C1)C([2H])([2H])C3([2H])[2H])([2H])N3C4=NSC5=CC=CC=C54
    InChi Code
    InChI=1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)/i7D2,8D2,9D2,10D2
    InChi Key
    MVWVFYHBGMAFLY-UFBJYANTSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years