Vardenafil (hydrochloride hydrate), 10MG

SKU:
CAY-14930-10MG
  • $106.00

    • Description

    Vardenafil (hydrochloride hydrate)

    Formal Name
    2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl-imidazo[5,1-f][1,2,4]triazin-4(1H)-one, monohydrochloride trihydrate
    CAS Number
    330808-88-3
    Molecular Formula
    C23H32N6O4S • HCl [3H2O]
    Formula Weight
    579.1
    Purity
    ≥98%
    Formulation(Request formulation change)
    A crystalline solid
    Solubility
    • DMF: 0.3 mg/ml
    • DMSO: 2 mg/ml
    • Ethanol: 0.5 mg/ml
    • PBS (pH 7.2): 10 mg/ml
    λmax
    215 nm
    SMILES
    CC(N=C1CCC)=C2N1N([H])C(C3=CC(S(=O)(N4CCN(CC)CC4)=O)=CC=C3OCC)=NC2=O.Cl.O.O.O
    InChi Code
    InChI=1S/C23H32N6O4S.ClH.3H2O/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28;;;;/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30);1H;3*1H2
    InChi Key
    FBCDRHDULQYRTB-UHFFFAOYSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years
    Product Description

    Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM).1,2,3 It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.4 Chronic vardenafil administration at a dose of 2 mg/kg for five weeks in subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.5 Formulations containing vardenafil have been used in the treatment of erectile dysfunction.

    WARNING This product is not for human or veterinary use.