Trimipramine-d₃ (maleate) is intended for use as an internal standard for the quantification of trimipramine (maleate) (Item No. 15921) by GC- or LC-MS. Trimipramine is a tricyclic antidepressant.^1,2,3 It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT; K_ds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H₁ receptor antagonist (K_i = 0.02 µM) that is selective for histamine H₁ over H₂, H₃, and H₄ receptors (K_is = 0.04, >100, and 43.6 µM, respectively).^1,2 Trimipramine binds to muscarinic acetylcholine and α₁- and α₂-adrenergic receptors (K_ds = 58, 24, and 580 nM, respectively), as well as dopamine D₁ and D₂ receptors and 5-HT receptor subtypes 5-HT_1C and 5-HT₂ (K_is = 346.7, 57.5, 537, and 19.5 nM, respectively).^1,3 It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg.⁴ Formulations containing trimipramine have previously been used in the treatment of depression.

WARNING This product is not for human or veterinary use.