Description
Trimipramine-d3 (maleate)
Product Description
Trimipramine-d3 (maleate) is intended for use as an internal standard for the quantification of trimipramine (maleate) (Item No. 15921) by GC- or LC-MS. Trimipramine is a tricyclic antidepressant.1,2,3 It selectively binds the serotonin (5-HT) transporter (SERT) over the norepinephrine transporter (NET) and dopamine transporter (DAT; Kds = 149, 2,450, and 3,780 nM, respectively) and acts as a histamine H1 receptor antagonist (Ki = 0.02 µM) that is selective for histamine H1 over H2, H3, and H4 receptors (Kis = 0.04, >100, and 43.6 µM, respectively).1,2 Trimipramine binds to muscarinic acetylcholine and α1- and α2-adrenergic receptors (Kds = 58, 24, and 580 nM, respectively), as well as dopamine D1 and D2 receptors and 5-HT receptor subtypes 5-HT1C and 5-HT2 (Kis = 346.7, 57.5, 537, and 19.5 nM, respectively).1,3 It reduces immobility time in the forced swim test in rats when administered at a dose of 10 mg/kg.4 Formulations containing trimipramine have previously been used in the treatment of depression.
WARNING This product is not for human or veterinary use.
Technical Information
- DMSO: soluble
- Methanol: soluble