Thiamethoxam-d₃ is intended for use as an internal standard for the quantification of thiamethoxam (Item No. 25784) by GC- or LC-MS. Thiamethoxam is a neonicotinoid insecticide and a prodrug form of the neonicotinoid insecticide clothianidin (Item No. 29605).^1,2 It binds to nicotinic acetylcholine receptors (nAChRs) with low affinity (IC₅₀ = 5,000 nM for housefly head membranes) and does not activate non-desensitizing nAChRs in cockroach neurons in vitro (IC₅₀ = >3,000 nM).² Thiamethoxam induces mortality in a variety of insects, including A. craccivora, M. persicae, and S. littoralis when administered in contact/feeding assays (LC₈₀s = 12, 3, and 3 mg AI/L, respectively) and via systemic administration (LC₈₀s = 0.8, 0.2, and 0.8 mg AI/L, respectively), as well as N. lugens and D. balteata in contact/feeding assays (LC₈₀s = 0.8 mg AI/L for both).¹ Thiamethoxam also induces 100% mortality of second instar larvae of the fall armyworm S. frugiperda and the tobacco budworm H. virescens in leaf-dip bioassays when used at a concentration of 200 mg/L.² Formulations containing thiamethoxam have been used in the control of insects in agriculture.

WARNING This product is not for human or veterinary use.

This product is sold exclusively for research and analytical uses. It is formulated and packaged for use in controlled laboratory settings. Bulk sizes are not available for purchase.