Description
34865 Sigma-Aldrich
Tetrahydrofuran
inhibitor-free, for HPLC, ≥99.9%
Synonym: Butylene oxide, Oxolane, THF, Tetramethylene oxide
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CAS Number 109-99-9
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Empirical Formula (Hill Notation) C4H8O
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Molecular Weight 72.11
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Beilstein/REAXYS Number 102391
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EC Number 203-726-8
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MDL number MFCD00005356
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PubChem Substance ID 329755073
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NACRES NA.21
Description
General description
Tetrahydrofuran (THF) is widely employed as a solvent. It constitutes the key fragment of various natural products (polyether antibiotics).[1] THF forms a double hydrate with hydrogen sulfide. Crystal structure of this double hydrate has been investigated by three-dimensional single-crystal studies.[2] Butane-1,4-diol is formed as an intermediate during the synthesis of THF.[5] Hot THF is useful for the dissolution of polyvinylidene chloride (PVDV).[6]
Application
Suitable for HPLC, spectrophotometry, environmental testing
Tetrahydrofuran may be used for the dissolution of poly-ε-caprolactone (PCL) and 1,3-diaminopentane, during the preparation of poly-ε-caprolactone (PCL)-hydroxyapatite (HA) scaffolds[3] and acrylate-terminated poly(5-amino-1-pentanol-co-1,4-butanediol diacrylate) (C32)- 1,3-diaminopentane (117) polymer,[4] respectively.
Packaging
1, 6×1, 2, 4×2.5, 4, 4×4 L in glass bottle
20 L in Nowpak™
100, 12×100 mL in glass bottle
200 L in Pure-Pac™ 1
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Properties
Related Categories | Analytical Reagents, Analytical/Chromatography, Chromatography Reagents & Solvents, HPLC Plus Grade Solvents, HPLC Solvents, |
grade | for HPLC |
vapor density | 2.5 (vs air) |
vapor pressure | 114 mmHg ( 15 °C) |
143 mmHg ( 20 °C) | |
InChI Key | WYURNTSHIVDZCO-UHFFFAOYSA-N |
assay | ≥99.9% |
autoignition temp. | 610 °F |
expl. lim. | 11.8 % |
impurities | ≤0.0005% non-volatile matter |
≤0.002% free acid (as CH3COOH) | |
≤0.05% peroxides (as H2O2) | |
≤0.05% water (Karl Fischer) | |
evapn. residue | ≤0.0005% |
color | APHA: ≤10 |
refractive index | n20/D 1.407 (lit.) |
bp | 65-67 °C (lit.) |
mp | −108 °C (lit.) |
density | 0.889 g/mL at 25 °C (lit.) |
UV absorption | λ: 245 nm Amax: ≤0.26 |
λ: 275 nm Amax: ≤0.046 | |
λ: 315 μm Amax: ≤0.0044 | |
suitability | complies for IR spectroscopy |
Featured Industry | Food and Beverages |