Silymarin, 10g

SKU:
S0292-10G
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    • Description

    Silymarin

    flavonolignans
     
    Synonym(s):
    flavolignans
    CAS Number:
    65666-07-1
    MDL number:
    MFCD01776359
    NACRES:
    NA.81

    Properties

    biological source

    plant (Silybum marianum)

    Quality Level

    200

    form

    powder

    technique(s)

    toxicology assay: suitable

    application(s)

    microbiology

    storage temp.

    −20°C

    General description

    Silymarin is a flavonolignan, obtained from milk thistle (Silybum marianum) plant.

    Application

    Silymarin has been used to study:
    • its in vitro antiviral, antibacterial, antifungal activities and cytotoxicity
    • its effect of silymarin on bladder contractions in cyclophosphamide (CYP)-induced cystitis rat model
    • its effect on liver toxication induced by Fumonisin B1 in mice 

    Biochem/physiol Actions

    Silymarin is originally known to protect liver from various toxic agents and is used in treating hepatitis and cirrhosis. Silymarin possesses many biological actions such as antifibrotic, anti-lipid peroxidative, anti-inflammatory, immunomodulatory and membrane stabilizing. Silymarin also aids in liver regeneration.
    Silymarin provides cardioprotective activity against ischemia-reperfusion induced myocardial infarction in rats.
    Silymarin was shown to protect the liver from the cytotoxic effects of anti-tuberculosis drugs by decreasing serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels. This effect was related to the anti-oxidant effects of silymarin. 

    Other Notes

    Mixture of anti-hepatotoxic flavonolignans from the fruit of Silybum marianum.