Sildenafil Citrate, 500MG

SKU:
PHR1807-500MG
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    • Description

    Sildenafil Citrate

    Pharmaceutical Secondary Standard; Certified Reference Material

    Synonym(s):
    Sildenafil citrate salt, 1-[[3-(4,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-methylpiperazine citrate salt, 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-one citrate salt, Revatio, UK-92,480
    Empirical Formula (Hill Notation):
    C22H30N6O4S ·C6H8O7
    CAS Number:
    171599-83-0
    Molecular Weight:
    666.70
    MDL number:
    MFCD09026931
    PubChem Substance ID:
    329823626

    PROPERTIES

    Gene Information

    human ... PDE5A(8654)

    grade

    certified reference material
    pharmaceutical secondary standard

    Quality Level

    300

    Agency

    traceable to Ph. Eur. Y0001578
    traceable to USP 1612561

    API family

    sildenafil

    form

    solid

    CofA

    current certificate can be downloaded

    packaging

    pkg of 500 mg

    technique(s)

    HPLC: suitable
    gas chromatography (GC): suitable

    application(s)

    pharmaceutical (small molecule)

    storage temp.

    2-8°C

    SMILES string

    OC(=O)CC(O)(CC(O)=O)C(O)=O.CCCc1nn(C)c2C(=O)NC(=Nc12)c3cc(ccc3OCC)S(=O)(=O)N4CCN(C)CC4

    InChI

    1S/C22H30N6O4S.C6H8O7/c1-5-7-17-19-20(27(4)25-17)22(29)24-21(23-19)16-14-15(8-9-18(16)32-6-2)33(30,31)28-12-10-26(3)11-13-28;7-3(8)1-6(13,5(11)12)2-4(9)10/h8-9,14H,5-7,10-13H2,1-4H3,(H,23,24,29);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)

    InChI key

    DEIYFTQMQPDXOT-UHFFFAOYSA-N

    General description

    Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

    Application

    These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

    Biochem/physiol Actions

    Sildenafil is a potent, selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5). Sildenafil is used to treat erectile dysfunction and pulmonary arterial hypertension. NO activates guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation. Sildenafil enhances the effect of NO by inhibiting PDE5, which is responsible for degradation of cGMP.

    Analysis Note

    These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

    Other Notes

    This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

    Footnote

    To see an example of a Certificate of Analysis for this material enter LRAB9121 in the Documents slot below. This is an example certificate only and may not be the lot that you receive.

    Recommended products

    Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.