Sibutramine hydrochloride solution 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant

SKU:
S-011-1ML
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    • Description

    Sibutramine hydrochloride solution

    1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

    Synonym(s):
    Sibutramine hydrochloride monohydrate, 1-(4-Chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)cyclobutanemethanamine hydrochloride monohydrate, Meridia, Reductil
    Empirical Formula (Hill Notation):
    C17H26ClN · HCl
    CAS Number:
    84485-00-7
    Molecular Weight:
    316.31
    EC Number:
    200-659-6
    MDL number:
    MFCD04039806
    PubChem Substance ID:
    329824413
    NACRES:
    NA.24

    PROPERTIES

    grade

    certified reference material

    Quality Level

    300

    form

    liquid

    feature

    Snap-N-Spike®/Snap-N-Shoot®

    packaging

    ampule of 1 mL

    manufacturer/tradename

    Cerilliant®

    concentration

    1.0 mg/mL in methanol (as free base)

    technique(s)

    gas chromatography (GC): suitable
    liquid chromatography (LC): suitable

    application(s)

    clinical testing

    format

    single component solution

    storage temp.

    −20°C

    SMILES string

    O.Cl.CC(C)CC(N(C)C)C1(CCC1)c2ccc(Cl)cc2

    InChI

    1S/C17H26ClN.ClH.H2O/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;;/h6-9,13,16H,5,10-12H2,1-4H3;1H;1H2

    InChI key

    KFNNPQDSPLWLCX-UHFFFAOYSA-N

    Gene Information

    human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

    General description

    Sibutramine, a SNRI and anorectant, was marketed as a treatment for obesity until 2010 when it was removed from the market over concerns of potential adverse cardiovascular side effects. Sold under trade names Reductil, Meridia®, and Subitrex, this sibutramine Snap-N-Spike® reference solution is applicable for use in LC/MS or GC/MS applications for clinical toxicology and forensic analysis.

    Biochem/physiol Actions

    Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.

    Legal Information

    CERILLIANT is a registered trademark of Cerilliant Corporation
    Meridia is a registered trademark of Abbott Laboratories Corp.
    Snap-N-Shoot is a registered trademark of Cerilliant Corporation
    Snap-N-Spike is a registered trademark of Cerilliant Corporation

    SAFETY INFORMATION

    Pictograms

    GHS02,GHS06,GHS08

    Signal Word

    Danger

    Hazard Statements

    H225 - H301 + H311 + H331 - H370

    Precautionary Statements

    P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311

    Hazard Classifications

    Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

    Target Organs

    Eyes

    Storage Class Code

    3 - Flammable liquids

    WGK

    WGK 1

    Flash Point(F)

    49.5 °F - closed cup

    Flash Point(C)

    9.7 °C - closed cup