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Sertraline-d3 (hydrochloride)

SKU:
CAY-15857-1MG
  • $190.00

    • Description

    Sertraline-d3 (hydrochloride)

    Sertraline-d3 is intended for use as an internal standard for the quantification of sertraline (Item No. 14839) by GC- or LC-MS. Sertraline is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits monoamine uptake by the serotonin transporter (SERT) with an IC50 value of 70 nM.1 It is selective for SERT over the norepinephrine and dopamine transporters (IC50s = 520 and 720 nM, respectively). Sertraline (3.2-56 mg/kg, s.c.) reduces immobility in the forced swim test in mice.2 Sertraline (5 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide.3 Formulations containing sertraline have been used in the treatment of depression, obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), and various anxiety disorders.

    WARNING This product is not for human or veterinary use.

    Technical Information
    Formal Name
    (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-d3-1-naphthalenamine, monohydrochloride
    CAS Number
    1217741-83-7
    Molecular Formula
    C17H14Cl2D3N • HCl
    Formula Weight
    345.7
    Purity
    ≥99% deuterated forms (d1-d3)
    Formulation(Request formulation change)
    A solid
    Solubility(Learn about Variance in Solubility)
    • Methanol: soluble
    SMILES
    ClC(C=C1)=C(Cl)C=C1[C@H](CC[C@@H]2NC([2H])([2H])[2H])C3=C2C=CC=C3.Cl
    InChi Code
    InChI=1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1/i1D3;
    InChi Key
    BLFQGGGGFNSJKA-FEGLBNOFSA-N
    Shipping & Storage Information
    Storage
    -20°C
    Shipping
    Room Temperature in continental US; may vary elsewhere
    Stability
    ≥ 4 years