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(R)-(+)-WIN 55,212-2 mesylate salt (HPLC), 25MG

SKU:
W102-25MG
  • $446.00

    • Description

    (R)-(+)-WIN 55,212-2 mesylate salt ≥98% (HPLC), 25MG

    Synonym(s):
    WIN 552122 mesylate, (R)-(+)-[2,3-Dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone mesylate salt, WIN 55212-2 methanesulfonate
    Linear Formula:
    C27H26N2O3 · CH3SO3H
    CAS Number:
    131543-23-2
    Molecular Weight:
    522.61
    MDL number:
    MFCD00153882
    PubChem Substance ID:
    24278779

    Quality Level

    100

    assay

    ≥98% (HPLC)

    form

    powder

    drug control

    regulated under CDSA - not available from Sigma-Aldrich Canada

    color

    white to beige

    solubility

    0.1 M HCl: 0.25 mg/mL
    DMSO: 12 mg/mL
    45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2.4 mg/mL
    0.1 M NaOH: insoluble
    H2O: insoluble

    SMILES string

    CS(O)(=O)=O.Cc1c(C(=O)c2cccc3ccccc23)c4cccc5OC[C@@H](CN6CCOCC6)n1c45

    InChI

    1S/C27H26N2O3.CH4O3S/c1-18-25(27(30)22-9-4-7-19-6-2-3-8-21(19)22)23-10-5-11-24-26(23)29(18)20(17-32-24)16-28-12-14-31-15-13-28;1-5(2,3)4/h2-11,20H,12-17H2,1H3;1H3,(H,2,3,4)/t20-;/m1./s1

    InChI key

    FSGCSTPOPBJYSX-VEIFNGETSA-N

    Gene Information

    human ... CNR1(1268) , CNR2(1269)

    WIN 55,212-2 is a member of the aminoalkylindole class of compounds.

    Application

    (R)-(+)-WIN 55,212-2 mesylate salt has been used as a high affinity cannabinoid agonist for intraperitoneal injection into rats to induce behavioural sensitization. It has also been used as a synthetic cannabinoid drug and cannabinoid receptor 1 (CNR1) agonist to treat Becn2+/− mice and wild-type (WT) littermate to analyze the levels of CNR1 in the brain.

    Packaging

    25 mg in poly bottle
    100 mg in glass bottle

    Biochem/physiol Actions

    It is known to decrease the lipopolysaccharide mediated release of tumor necrosis factor- α and interleukin-1 in mice.

    Features and Benefits

    This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

    Legal Information

    Sold with the permission of Sterling-Winthrop, Inc.

    Personal Protective Equipment

    dust mask type N95 (US),Eyeshields,Gloves

    RIDADR

    NONH for all modes of transport

    WGK Germany

    WGK 3

    Flash Point(F)

    Not applicable

    Flash Point(C)

    Not applicable